The questions I work on, and the projects they have grown into.
The questions that drive my programme of work.
How sustained pressure overload reshapes myocardial structure, and which of those changes are reversible.
The signalling pathways through which endothelial cells sense and respond to shear stress.
Multi-scale models that link ion-channel kinetics to whole-organ function and clinical measurement.
Evidence-based approaches to teaching physiology, with a focus on retrieval practice and concept inventories.
Funded studies and ongoing lines of enquiry.
FeaturedA five-year programme asking whether the structural changes induced by chronic pressure overload can be reversed once the load is relieved, and which molecular signatures predict recovery. The study combines a rodent model of aortic banding with longitudinal echocardiography and single-nucleus transcriptomics.
Funded by National Institutes of Health
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FeaturedBuilding and validating a computational model that links mechanosensitive ion-channel behaviour to vessel-level flow responses, with the aim of predicting where atherosclerotic lesions form.
Funded by National Science Foundation
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Development and psychometric validation of a concept inventory that measures whether medical students hold durable mental models of cardiovascular regulation — not just recall of facts.
Funded by Example University Teaching Innovation Fund
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